Endocrine Abstracts

BackgroundPituitary adenomas are general benign tumors. However, gross invasion at time of operation is observed in up to 35% of pituitary adenomas. The new WHO classification describes pituitary tumor subtypes along with histological markers, such as Ki67 > 3%, that may suggest a potential for aggressive clinical behavior. The expression of EGFR in tumor microenvironment of pituitary adenomas ant its correlation with tumor behavior have been poorly ...

The Case Study: We report the case of a 68-year-old female referred to the E.R. department with severe neurological problems. Patient’s neurological status revealed that patient was disoriented in time and place, with emotional irritability and an asymmetric eye fissure, and not feeling well without any obvious reason. A preliminary CT scan with I/V contrast was done and acute neurological damage was excluded. In the lab, there were: hypokalemia, hypomagnesemia, increased...

Background: Pituitary adenomas(PAs) comprise 10%–25% of all intracranial tumors, the majority of them being benign. But 35% of all PAs are considered invasive, having a higher recurrence rate than benign ones.Objectives: We analyzed the expression of different angiogenic growth factors and their receptors in PAs and identified correlations with the hormone profile that could explain their behavior and prognosis.Methods: Our st...

Introduction: Chronic kidney disease (CKD) is characterised by an ongoing reduction in kidney function and is associated with comorbidities such as muscle wasting that greatly increase mortality. Both acidosis and elevated glucocorticoids levels are hallmarks of CKD and implicated as having a synergistic role in driving muscle wasting. We investigated the synergistic effects of acidosis and the glucocorticoid cortisol on muscle metabolism and fibre size using ...

Paraganglioma (PGL) are rare neuroendocrine tumors with an estimated prevalence of 1:6500, with cardiac PGL being even rarer. Although most PGL are benign, approximately 15–35% of PGLs have metastatic disease, with few effective treatment options. Novel therapeutic indications, such as 177Lu-DOTA-TATE for patients with PGL, has been investigated in several clinical trials. A 66-year-old woman was referred to Cardiology in 2011 due to an incidentaloma adjacent to the right...

Background: In the last decade, immunotherapy proved to be the frontline in the fight against cancer in a rocketing area of cancer types. Boosting the body’s inherent immune system, a new set of toxicities raised, labeled as immune-related adverse events (irAEs). Endocrine disorders, particularly thyroid dysfunctions, are by far the most frequent irAEs during immune checkpoint inhibitors (ICIs) therapy. New research data explored their predictive impact in cancer patients...

Introduction: Deficiency of 11-beta hydroxylase (11-HD) accounts for 5% of the causes of congenital adrenal hyperplasia (CAH), with an incidence of 1:100,000. The classic form phenotype consists in an excess of androgens and mineralocorticoids, which clinically translates into hypertension and hypokalaemia. In boys, there may be an increase in penis size, early adrenarche, increased growth velocity, and advancing bone age.Clinical case: We present a case...

Background: Endocrine pathologies are a common cause of secondary hypertension. Most patients with primary aldosteronism and primary hyperparathyroidism suffer from hypertension. Although the coexistence of parathyroid adenoma and cones syndrome in the same patient is uncommon, the occurrence of these two adenomas at the same time can have significant implications for the patient’s clinical presentation, diagnostic evaluation, and treatment approach.<p class="abstext"...

Background: Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. There’s an overlap between benign and malignant disease clinical presentation, but the presence of very high calcium levels (>14 mg/dl), markedly raised levels of PTH, palpable neck mass or severe bone/kidney disease is more common in parathyroid carcinoma. We present a case of primary hyperparathyroidism due to a parathyroid carcinoma, with unusual presentation.Ca...

We present a case of a 70-year-old female patient without comorbidities who was admitted to our institution following head trauma leading to subsequent subarachnoid hemorrhage and vertigo. Conservative management was implemented successfully. Throughout the hospitalization, lab monitoring revealed the emergence of hyponatremia which was corrected by fluid restriction and hypertonic solution administration. The patient was discharged without residual vertiginous complications. ...